refZ

refZ
168

regulator of FtsZ (TetR family), facilitates switch from medial to polar FtsZ ring placement during sporulation

Locus
BSU_29630
Molecular weight
24.24 kDa
Isoelectric point
6.71
Protein length
207 aaSequenceBlast
Gene length
624 bpSequenceBlast
Function
relocalization of the FtsZ ring, placement of the sporulation septum
Product
regulator of FtsZ
Essential
no
Synonyms
refZ, yttP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,032,417 → 3,033,040
The protein
Catalyzed reaction/ biological activity
facilitates switch from medial to polar FtsZ ring placement during sporulation PubMed
binds to specific DNA motifs (RBMs) that localize near the poles at the time of septation PubMed
facilitates the timely assembly of polar Z-rings and partially defines the region of chromosome initially captured in the forespore PubMed
a refZ noc double mutant is defective in cell division and exhibits reduced sporulation PubMed
Protein family
TetR family
Domains
TetR-like DNA-binding helix-turn-helix domain at the N-terminus PubMed
HTH tetR-type domain (aa 3-63) (according to UniProt)
Structure
6MJ1 (PDB)
O34970 (AlphaFold)
Localization
polar foci PubMed
at the side of asymmetric septum formation at the mother cell side of the septum (depends on SpoIIE) PubMed
Expression and Regulation
Operons
Genes
refZ
Description
PubMed
Regulation
expressed under conditions of phosphate limitation (PhoP) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Spo0A: activation, PubMed, in spo0A regulon
PhoP: activation, PubMed, in phoP regulon
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refZ

2025-03-10 01:52:26

ghost

113

fcf30a6ba4d335bf69b7a9553cc290e64f49a9f0

9CF59A71B0ED31690A3D816F1393AB51D42205D9

Biological materials
Mutant
MGNA-A426 (yttP::erm), available at the NBRP B. subtilis, Japan
BKE29630 (ΔrefZ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACGGCTCACTCCTTCCT,  downstream forward: _UP4_AACTAGCACCGTTCCAAAAA
BKK29630 (ΔrefZ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACGGCTCACTCCTTCCT,  downstream forward: _UP4_AACTAGCACCGTTCCAAAAA
References
Reviews
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Original Publications
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C5F67C3ACB06A5029B4AE69A065BC55622372404

Page visits: 4021

Time of last update: 2025-04-02 11:47:26

Author of last update: Jstuelk