qoxA

qoxA
168

cytochrome aa3 quinol oxidase (subunit II)

Locus
BSU_38170
Molecular weight
36.10 kDa
Isoelectric point
4.8
Protein length
321 aaSequenceBlast
Gene length
966 bpSequenceBlast
Function
respiration
Product
cytochrome aa3 quinol oxidase (subunit II)
Essential
no
E.C.
1.10.3.-
Synonyms
qoxA, ipa-37d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1622 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,917,296  3,918,261
Phenotypes of a mutant
inactivation of ''qoxA restores beta-lactam resistance in a sigM'' mutant PubMed
The protein
Catalyzed reaction/ biological activity
2 quinol + O2 --> 2 quinone + 2 H2O (according to UniProt)
Protein family
cytochrome c oxidase subunit 2 family (with CtaC, according to UniProt)
Structure
1FFT (PDB) (QoxA-QoxB-QoxC complex from E. coli, 35% identity) PubMed
P34957 (AlphaFold)
Localization
cell membrane PubMed
Additional information
the QoxA-QoxB-QoxC-QoxD cytochrome aa3 oxidase complex is sensitive to increased intracellular Mn2+ concentrations, this results in the generation of toxic reactive radicals PubMed
Expression and Regulation
Operons
Genes
qoxA-qoxB-qoxC-qoxD
Description
PubMed
Regulation
RelA dependent downregulation (Class I) during stringent response PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
CitB: translation control, [pubmed|], in citB regulon
Additional information
the presence of an iron-responsive element bound by CitB between ''feuA and feuB'' suggests iron-dependent regulation by CitB PubMed
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qoxA→qoxD

2025-03-12 22:05:13

ghost

127

528706cf2ce16a4799a79387ef081442d5a898c0

DCA1ED001F8B0E6CA914E7163B3631C2F439B710

Biological materials
Mutant
BKE38170 (qoxA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACCATCCTTCCTATTGATG,  downstream forward: _UP4_TGATATTGATCAGGAAAGGA
BKK38170 (qoxA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACCATCCTTCCTATTGATG,  downstream forward: _UP4_TGATATTGATCAGGAAAGGA
References
Reviews
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Original Publications
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48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175

Page visits: 3921

Time of last update: 2025-04-02 12:56:06

Author of last update: Jstuelk