pksF

pksF
168

involved in polyketide synthesis

Locus
BSU_17140
Molecular weight
44.97 kDa
Isoelectric point
5.37
Protein length
416 aaSequenceBlast
Gene length
1248 bpSequenceBlast
Function
polyketide synthesis
Product
unknown
Essential
no
Synonyms
pksF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0304 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,788,695 → 1,789,942
The protein
Catalyzed reaction/ biological activity
H+ + malonyl-[ACP] --> acetyl-[ACP] + CO2 (according to UniProt)
Protein family
thiolase-like superfamily (according to UniProt)
Structure
4LS5 (PDB) (FabF, 30% identity) PubMed
P40804 (AlphaFold)
Expression and Regulation
Operons
Genes
pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
Description
PubMed
Regulation
expressed during the transition from growth to stationary phase (AbrB, CodY) PubMed
heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
CodY: activation, PubMed, in codY regulon
Additional information
this is a very large operon comprising about 75 kb
Open in new tab

pksC→pksR

2025-03-17 18:36:51

Jstuelk

162

74BF817D9000509D225BBBCAC6C8A0A9EABEB843

1475C94AAA2C10C6BE3CA0873EFBD171EC2E2513

Genes
pksB-pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
Description
PubMed
Open in new tab

pksB→pksR

2025-03-17 03:33:23

Jstuelk

136

c851e07b7201353cf026d8929ea66cff6bbb92e2

D95CF77A7673AA84CC653095A1FB017D490049D6

Biological materials
Mutant
BKE17140 (ΔpksF::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AACGCCTACACCGGTCACCA,  downstream forward: _UP4_GAGAAATGTGGAGGCGAATC
BKK17140 (ΔpksF::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AACGCCTACACCGGTCACCA,  downstream forward: _UP4_GAGAAATGTGGAGGCGAATC
References
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85D6E439529E8B3F73244A0B004B394B4FE65509

Page visits: 3446

Time of last update: 2025-03-31 22:37:17

Author of last update: Melvin.boenninger