opuBC

opuBC
168

choline and arsenocholine ABC transporter (binding protein)

Locus
BSU_33710
Molecular weight
34.25 kDa
Isoelectric point
6.62
Protein length
306 aaSequenceBlast
Gene length
921 bpSequenceBlast
Function
compatible solute transport
Product
choline and arsenocholine ABC transporter (binding protein)
Essential
no
Synonyms
opuBC, proX
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1732 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,460,503 → 3,461,423
The protein
Catalyzed reaction/ biological activity
uptake of choline and arsenocholine PubMed
Protein family
OsmX family (with OpuCC, according to UniProt)
Structure
3R6U (PDB), 6EYQ (PDB) (in complex with choline) PubMed
5NXX (PDB) (in complex with arsenocholine) PubMed
6EYL (PDB) (in complex with carnitine)
6EYG (PDB) (mutant in complex with betaine)
6EYH (PDB) (mutant in complex with dimethylsulfoniopropionate)
Q45462 (AlphaFold)
Paralogous protein(s)
OpuCC
Localization
associated to the membrane (via OpuBB-OpuBD) PubMed
lipoprotein PubMed
Expression and Regulation
Operons
Genes
opuBA-opuBB-opuBC-opuBD
Description
PubMed
Regulation
induced by choline (GbsR) PubMed
Regulatory mechanism
GbsR: repression, (transcriptional roadblock) PubMed, in gbsR regulon
OpcR: repression, (sterical interference with RNA polymerase access) PubMed, in opcR regulon
RemA: activation, PubMed, in remA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
An antisense RNA is predicted for'opuBD' PubMed
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opuBA→opuBD

2025-03-17 17:50:11

ghost

90

f5d474616565c5e32550f1c34aef09f972669a8e

1F7D81939583251B3B9B9F3D0D915C77CF89D428

Biological materials
Mutant
BKE33710 (ΔopuBC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTTCTTTTCATGAGCCGCC,  downstream forward: _UP4_GAATCGTGAAAGGGGGAAGA
BKK33710 (ΔopuBC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTTCTTTTCATGAGCCGCC,  downstream forward: _UP4_GAATCGTGAAAGGGGGAAGA
References
Reviews
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Original Publications
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C48798FE13B1521236F5BC5786B9A02D7BC9A336

Page visits: 3390

Time of last update: 2025-04-02 16:56:07

Author of last update: Jstuelk