menA

menA
168

probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Locus
BSU_38490
Molecular weight
33.68 kDa
Isoelectric point
9.32
Protein length
311 aaSequenceBlast
Gene length
936 bpSequenceBlast
Function
biosynthesis of menaquinone
Product
probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
Essential
yes
E.C.
2.5.1.74
Synonyms
menA, ywaB, ipa-6d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1575 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,950,726  3,951,661
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
1,4-dihydroxy-2-naphthoate + all-trans-polyprenyl diphosphate + H+ --> 2-demethylmenaquinol + CO2 + diphosphate (according to UniProt)
Protein family
MenA family (single member, according to UniProt)
Structure
3BYV (PDB) (from Toxoplasma gondii, 30% identity in a 25% fragment) PubMed
P39582 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
menA
Description
PubMed
Regulation
the leader mRNA is processed by RNase Y, this requires the RicA-RicF-RicT complex PubMed
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menA

2025-03-14 10:00:18

Jstuelk

88

e47e71b9a9eec10197df0defe443726d1c0cdce7

953F906DF6629B346FA553CC0C73DE6B81A8F9AB

Biological materials
Mutant
MGNA-B217 (ywaB::erm), available at the NBRP B. subtilis, Japan
References
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Time of last update: 2025-03-31 23:53:35

Author of last update: Jstuelk