iolC

iolC
168

formation of 2-deoxy-5-keto-gluconic acid-6-phosphate (5th reaction)

Locus
BSU_39740
Molecular weight
35.48 kDa
Isoelectric point
4.78
Protein length
325 aaSequenceBlast
Gene length
978 bpSequenceBlast
Function
myo-inositol catabolism
Product
formation of 2-deoxy-5-keto-gluconic acid-6-phosphate (5th reaction)
Essential
no
E.C.
2.7.1.92
Synonyms
iolC, yxdC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0524 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,081,029  4,082,006
The protein
Catalyzed reaction/ biological activity
5-dehydro-2-deoxy-D-gluconate + ATP --> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H+ (according to UniProt)
Protein family
carbohydrate kinase PfkB family (according to UniProt)
Structure
2QCV (PDB) (from Bacillus halodurans c-125 mutant, 73% identity, 85% similarity)
P42414 (AlphaFold)
Expression and Regulation
Operons
Genes
iolA-iolB-iolC-iolD-iolE-iolF-iolG-iolH-iolI-iolJ
Description
PubMed
Regulation
induced by inositol (IolR) PubMed
Regulatory mechanism
IolR: repression, PubMed, in iolR regulon
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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iolA→iolJ

2025-03-17 20:07:06

ghost

121

4fd092965338ef1511600132442d2247a2693c98

C19E63046F0B412961D2626F72E0308D922D50B2

Biological materials
Mutant
MGNA-B772 (iolC::erm), available at the NBRP B. subtilis, Japan
BKE39740 (iolC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCGTAAACAGCCACTCCT,  downstream forward: _UP4_TAATTGAAAAAGATCGAGTA
BKK39740 (iolC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCGTAAACAGCCACTCCT,  downstream forward: _UP4_TAATTGAAAAAGATCGAGTA
Labs working on this gene/protein
Yasutaro Fujita, University of Fukuyama, Japan
[[Ken-ichi Yoshida]], Kobe University, Japan
References
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AAE60753464EAA32379521531FDCAF64534D5F40

Page visits: 3337

Time of last update: 2025-03-29 20:33:47

Author of last update: Melvin.boenninger