bmrA

bmrA
168

multidrug ABC transporter (ATP-binding protein)

Locus
BSU_34820
Molecular weight
64.34 kDa
Isoelectric point
6.47
Protein length
589 aaSequenceBlast
Gene length
1770 bpSequenceBlast
Function
multiple antibiotic resistance
Product
multidrug ABC transporter (ATP-binding protein)
Essential
no
Synonyms
bmrA, yvcC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1132 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,577,745 → 3,579,514
The protein
Protein family
ABC transporter superfamily (according to UniProt)
Domains
has both a membrane-spanning and an ATP-binding domain PubMed
ABC transmembrane type-1 domain (aa 29-309) (according to UniProt)
ABC transporter domain (aa 341-576) (according to UniProt)
Structure
6R72 (PDB) PubMed
O06967 (AlphaFold)
Paralogous protein(s)
YknU, YfiC, YwjA, YknV, YgaD, YfiB, BmrC
Localization
membrane PubMed
Expression and Regulation
Operons
Genes
bmrA-yvcD
Description
PubMed
Regulation
constitutively expressed PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
half-life of the mRNA: 1.5 min PubMed
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bmrA->yvcD

2025-03-17 18:10:36

Bzhu

109

cbb28df201cbb41f921589502974e179e1c5f328

D27A0048010333EF6A841E0CD3BADFB4A82AC446

Biological materials
Mutant
MGNA-B645 (yvcC::erm), available at the NBRP B. subtilis, Japan
BKE34820 (ΔbmrA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATATTTTCCTCCTGTTT,  downstream forward: _UP4_TAAATTTTGGTCGAATCAGC
BKK34820 (ΔbmrA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATATTTTCCTCCTGTTT,  downstream forward: _UP4_TAAATTTTGGTCGAATCAGC
References
Reviews
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Original Publications
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ED1F82463BAA28B67184BFAB5CB23CF26A62999D

Page visits: 4939

Time of last update: 2025-03-30 19:53:24

Author of last update: Jstuelk