bkdAB
168

2-oxoisovalerate dehydrogenase (E1 beta subunit)

Locus

BSU_24040

Molecular weight

35.70 kDa

Isoelectric point

4.79

Protein length

327 aaSequenceBlast

Gene length

984 bpSequenceBlast

Function

utilization of branched-chain keto acids

Product

2-oxoisovalerate dehydrogenase (E1 beta subunit)

Essential

E.C.

1.2.4.4

Synonyms

bkdAB, bfmBAB, bfmB1b, bkd

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0022 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,498,093 2,499,076

Phenotypes of a mutant

a strain lacking the ptb-bcd-buk-lpdV-bkdAA-bkdAB-bkdB operon and the des gene exhibits strongly reduced membrane fluidity and eventual growth arrest PubMed

The protein

Catalyzed reaction/ biological activity

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N⁶-lipoyl-L-lysine + H⁺ --> [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N⁶-(S⁸-2-methylpropanoyldihydrolipoyl)-L-lysine + CO₂ (according to UniProt)

Structure

3DUF (PDB) (Geobacillus stearothermophilus PdhC, 36% identity) PubMed

P37941 (AlphaFold)

Paralogous protein(s)

PdhB, AcoB

Localization

Cytoplasm (Homogeneous) PubMed

Expression and Regulation

Operons

Genes

ptb-bcd-buk-lpdV-bkdAA-bkdAB-bkdB

Description