liaR

liaR
168

two-component response regulator, regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon in response to bacitracin

Locus
BSU_33080
Molecular weight
22.98 kDa
Isoelectric point
4.96
Protein length
211 aaSequenceBlast
Gene length
636 bpSequenceBlast
Function
regulation of the liaI-liaH-liaG-liaF-liaS-liaR operon
Product
two-component response regulator
Essential
no
Synonyms
liaR, yvqC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2197 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,394,422  3,395,057
The protein
Catalyzed reaction/ biological activity
regulation of the  ''liaI-liaH-liaG-liaF-liaS-liaR'' operon in response to bacitracin
Domains
Response regulatory domain (aa 3-119) (according to UniProt)
HTH luxR-type domain (aa 143-208) (according to UniProt)
Structure
5HEV (PDB) (LiaR from Enterococcus faecium, 62% identity) PubMed
O32197 (AlphaFold)
Modification
phosphorylation on a Asp residue by LiaS
Paralogous protein(s)
YhcZ, YdfI, YxjL, LnrK
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
liaG-liaF-liaS-liaR
Description
PubMed
Regulation
''liaG'': constitutive
Regulatory mechanism
LiaR: activation, PubMed, in liaR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

liaG→liaR

2025-04-03 08:27:16

ghost

105

2f16b4fd354512d8414b5b6145620bdeaa475d46

AF84222759CC1E14AC8022D48DBA6522494204CA

Genes
liaI-liaH-liaG-liaF-liaS-liaR
Description
PubMed
Regulation
''liaG'': constitutive
Open in new tab

liaI→liaR

2025-04-03 08:12:04

ghost

126

844f52131490c84c9a0558a221a24520579ef3fd

F37C9323D2117C9590CDC8EC3E6B0E3F58AFC1F7

Biological materials
Mutant
MGNA-B034 (yvqC::erm), available at the NBRP B. subtilis, Japan
BKE33080 (liaR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCCCATTCTGACCATTTCAT,  downstream forward: _UP4_AATCATCTCGTGAATTAGGC
BKK33080 (liaR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCCCATTCTGACCATTTCAT,  downstream forward: _UP4_AATCATCTCGTGAATTAGGC
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
References
Reviews
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Original Publications
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49E70A20CC05DBE485953C0AE34E634EFB33C3B2

Page visits: 6159

Time of last update: 2025-04-08 10:45:59

Author of last update: Christoph.elfmann