MgsR

• Description: transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
  
  

Gene name	mgsR
Synonyms	yqgZ
Essential	no
Product	transcriptional regulator
Function	controls a subset of general stress genes
Gene expression levels in SubtiExpress: mgsR
Interactions involving this protein in SubtInteract: MgsR
MW, pI	14 kDa, 9.28
Gene length, protein length	378 bp, 126 aa
Immediate neighbours	trnSL-Gln1, yqgY
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigB regulon, MgsR regulon

The gene

Basic information

• Locus tag: BSU24770

Database entries

• BsubCyc: BSU24770

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed

• Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily

• Paralogous protein(s): Spx

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • MgsR-RpoA PubMed

• Localization:

Database entries

• BsubCyc: BSU24770

• Structure:

• UniProt: P54503

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mgsR PubMed

• Expression browser: mgsR PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • repressed by casamino acids PubMed
  • induced by stress (SigB) PubMed

• Regulatory mechanism:
  • MgsR: transcription activation PubMed
• Additional information:
  • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
  • MgsR is subject to rapid proteolytic degradation by ClpX-ClpP and ClpC-ClpP PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: