spoVM

spoVM
168

membrane curvature sensor, required for normal spore cortex and coat synthesis, inhibits the proteolytic activity of FtsH (adaptor protein)

Locus
BSU_15810
Molecular weight
2.88 kDa
Isoelectric point
11.03
Protein length
26 aaSequenceBlast
Gene length
81 bpSequenceBlast
Function
initiation of spore coat assembly
Product
membrane curvature sensor
Essential
no
Synonyms
spoVM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5844 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,655,446 → 1,655,526
Phenotypes of a mutant
reduction of sporulation efficiency due to defects in spore coat and cortex assembly PubMed
The protein
Catalyzed reaction/ biological activity
anchors the basement layer of the spore coat to the surface of the developing spore PubMed
preferentially binds to micron-scale convex membranes and marks the surface of the developing spore as the site for coat assembly PubMed
recruits SpoIVA to the spore coat PubMed
Domains
contains an amphipathic alpha-helix
Structure
2MVH (PDB) PubMed
P37817 (AlphaFold)
Localization
around the surface of the developing forespore PubMed
spore membrane, recognizes membrane curvature PubMed
spore coat (basement), localization depends on SpoIVA PubMed
Expression and Regulation
Operons
Genes
spoVM
Description
PubMed
Regulation
expressed in mother cell during sporulation (SigE, SpoIIID) PubMed
Regulatory mechanism
SpoIIID: activation, PubMed, in spoIIID regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
Open in new tab

spoVM

2025-03-09 17:09:22

ghost

81

765eaac68953360af2f43b4253db012421fa18f8

F25A4E93E1EF196ED1668EE05ED03F4A51C2677D

Biological materials
Mutant
BKE15810 (ΔspoVM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTTGTCCCCTCCTATA,  downstream forward: _UP4_TAATGCCCAGGGGTTCAAAG
BKK15810 (ΔspoVM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTTGTCCCCTCCTATA,  downstream forward: _UP4_TAATGCCCAGGGGTTCAAAG
References
Reviews
Loading
Original Publications
Loading

BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055

Page visits: 4040

Time of last update: 2025-04-08 19:24:09

Author of last update: Jstuelk