SwrAA/1

2010-01-04T14:46:27Z

Dbkearns:

* '''Description:''' control of motility, enhances [[sigD]] transcription <br/><br/>

{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''swrA''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvzD, swrAA, ifm''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || swarming motility protein
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || essential for swarming differentiation on solid surfaces
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 13 kDa, 8.4
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 336 bp, 112 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[minJ]]'', ''[[ctpB]]''
|-
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/yvzD_nucleotide.txt Gene sequence (+200bp) ]'''
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/yvzD_protein.txt Protein sequence]'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yvzD_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/>

=The gene=

=== Basic information ===

* '''Coordinates:'''

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14160]

=== Additional information===

This protein is functional in undomesticated strains of ''B.subtilis'' but not in laboratory strains, such as 168, because of a frameshift mutation. Therefore laboratory strains of ''B.subtilis'' are unable to swarm.

The frameshift in strain 168 is caused by a single insertion of an adenine in the codon for Tyr-12 which leads to the premature truncation of the protein in residue 13. In addition, the C-terminal section of ''swrAA'' was predicted to be an ORF (''[[yvzD]]'') by the genome project.

=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:'''

* '''Protein family:'''

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''

* '''Domains:'''

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:''' cytoplasm (according to Swiss-Prot)

=== Database entries ===

* '''Structure:'''

* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/O32266 O32266]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU35230]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:'''

* '''[[Sigma factor]]:'''

* '''Regulation:'''

* '''Regulatory mechanism:'''

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''

* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:'''

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>16357223,19389763,16030230,18567663,15066026,, 19389763 19749039 </pubmed>

[[Category:Pseudogenes]]

SubtiWiki - User contributions [en]

SwrAA/1