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pdxK

pyridoxine, pyridoxal, and pyridoxamine kinase

locus

BSU_38020

4.92

28.87 kDa

protein length

271 aa Sequence Blast

gene length

816 bp Sequence Blast

function

biosynthesis of pyridoxal phosphate

product

pyridoxine, pyridoxal, and pyridoxamine kinase

essential

2.7.4.7

synonyms

ywdB,ipa-52r,thiD

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.12|Biosynthesis of pyridoxal phosphate]

Gene

Coordinates

3,900,963 → 3,901,778

The protein

Catalyzed reaction/ biological activity

ATP + pyridoxal --> ADP + H⁺ + pyridoxal 5'-phosphate (according to UniProt)

Protein family

ThiD family (with [protein|97EDB4ACD64C5FA2E6014ED133DF18F602FF58BB|ThiD], according to UniProt)

Paralogous protein(s)

[protein|97EDB4ACD64C5FA2E6014ED133DF18F602FF58BB|ThiD]

Structure

[PDB|2I5B] [pubmed|16978644]

Additional information

subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]

Expression and Regulation

Operons

genes

[gene|FEDD589EA9982856730E809F21B7930F688FDC42|pdxK]

description

[Pubmed|3100393]

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Biological materials

Mutant

BKE38020 (Δ[gene|FEDD589EA9982856730E809F21B7930F688FDC42|pdxK]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCTTGAACCTCCATCA, downstream forward: _UP4_TAAAAAAAGGGGCTGCCTTA

BKK38020 (Δ[gene|FEDD589EA9982856730E809F21B7930F688FDC42|pdxK]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCTTGAACCTCCATCA, downstream forward: _UP4_TAAAAAAAGGGGCTGCCTTA

References

17012797,14973012,3100393,16978644