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leuS [Mon Aug 31 2015 13:56:21 GMT+0200 (CEST)]
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leuS [Mon Aug 31 2015 13:56:21 GMT+0200 (CEST)]

Leu-tRNA synthetase
locus
BSU30320
pI
4.86
mw
91.00 kDa
function
translation
product
leucyl-tRNA synthetase
essential
yes
ec
6.1.1.4
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|T-box]

    • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu) (according to Swiss-Prot)

    • Protein family

  • class-I aminoacyl-tRNA synthetase family (according to Swiss-Prot)

    • Structure

  • [PDB|2AJG] (from ''Escherichia coli'', 39% identity, 56% similarity) [Pubmed|16277600]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|leuS]'' [Pubmed|1317842]

    • Regulation

  • induced by leucine limitation ([protein|search|T-box]) [Pubmed|1317842]

    • Regulatory mechanism

  • [protein|search|T-box]: [SW|RNA switch], binding of uncharged tRNA-Leu results in transcription antitermination [Pubmed|1317842]

    • References

    Reviews

  • 19258532

    • Original Publications

  • 1317842