penicillin-binding protein PBP 4* (spore cortex)
product
penicillin-binding protein PBP 4* (spore cortex)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins][category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|cell wall degradation/ turnover], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|most abundant proteins], [SW|penicillin-binding proteins]This gene is a member of the following [SW|regulons]
[SW|SigW regulon]Gene
Coordinates on the chromosome (coding sequence)
3,534,118 -> 3,535,473
The protein
Protein family
beta-lactamase family (according to Swiss-Prot)Structure
[PDB|3TG9] (from ''Bacillus halodurans'', 27% identity, 59% similarity)[SW|Localization]
spore cortexExpression and Regulation
Operon
''[protein|search|pbpE]-[protein|search|racX]'' [Pubmed|8491712][SW|Sigma factor]
[protein|search|SigW] [Pubmed|8491712,12207695]Regulation
repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|7592498], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]induced by cell wall stress ([protein|search|SigW]) [Pubmed|8491712,12207695]Additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
8491712,12533473,9987136,19063962,12884008,12207695,7592498,20817675,15378759 
