SubtiBank SubtiBank
fabHB [Mon Aug 31 2015 13:53:27 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

fabHB [Mon Aug 31 2015 13:53:27 GMT+0200 (CEST)]

beta-ketoacyl-acyl carrier protein synthase III
locus
BSU10170
pI
5.68
mw
35.00 kDa
function
fatty acid biosynthesis
product
beta-ketoacyl-acyl carrier protein synthase III
essential
no
ec
2.3.1.180
synonyms
yhfB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]
    • syns
    yhfB

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of lipids]

    • This gene is a member of the following [SW|regulons]

  • [SW|FapR regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2 (according to Swiss-Prot)

    • Protein family

  • fabH family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [SW|FabHA], one of the two proteins has to be present for viability [Pubmed|17114254]

    • Structure

  • [PDB|1EBL] (FabH from ''E. coli'') [Pubmed|10673437]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Additional information

  • affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis [Pubmed|19820084]

    • Expression and Regulation

    Operon

  • ''fabHB'' [Pubmed|12737802]

    • Regulation

  • induced if the cells experience a lack of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]
  • induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]

    • Regulatory mechanism

  • [protein|search|FapR]: transcription repression [Pubmed|12737802]

    • References

    Reviews

  • 15952903,17919287

    • Original Publications

  • 12737802,17114254,10629181,10673437,19820084,21383089,25196128