conveys incoming ssDNA to RecA; facilitates the displacement of both SSBs (SsbB and SsbA), increases RecA nucleation onto SSB-coated ssDNA, and mediates DNA strand annealing, required to internalize and to recombine ssDNA with homologous resident duplex
function
DNA repair/ recombination
product
recombination mediator protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination], [SW|genetic competence]This gene is a member of the following [SW|regulons]
[SW|ComK regulon]Gene
Coordinates on the chromosome (coding sequence)
1,682,580 -> 1,683,473
Phenotypes of a mutant
strongly impaired genetic recombination [Pubmed|23779106]The protein
Catalyzed reaction/ biological activity
binds ssDNA, promotes displacement of [protein|search|SsbA] and [protein|search|SsbB] from ssDNA [Pubmed|23779106]provides [protein|search|RecA] access to ssDNA during chromosomal transformation (together with [protein|search|RecO]) [Pubmed|22373918]RecA-ATP in concert with [protein|search|DprA] and [protein|search|SsbA] catalyzes DNA strand exchange, with [protein|search|SsbB] as an accessory factor [Pubmed|25138221]Protein family
smf family (according to Swiss-Prot)[SW|Localization]
transiently localizes to the cell pole, and co-localizes with the DNA uptake machinery [Pubmed|17630974][SW|Interactions]
forms dimers [Pubmed|23779106][protein|search|DprA]-[protein|search|RecA] [Pubmed|17803906,17630974][protein|search|DprA]-[protein|search|DprA] [Pubmed|17803906][protein|search|DprA]-[SW|ComFA] [Pubmed|17630974][protein|search|SsbB]-[protein|search|DprA] [Pubmed|17630974]Expression and Regulation
Operon
''dprA'' (according to [http://dbtbs.hgc.jp/COG/prom/smf.html DBTBS])Regulation
expressed under conditions that trigger genetic competence ([protein|search|ComK]) [Pubmed|11948146]Regulatory mechanism
[protein|search|ComK]: transcription activation [Pubmed|11948146]Labs working on this gene/protein
[SW|Peter Graumann], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]References
17630974,17803906,12421306,18045469,11948146,22373918,23779106,23440217,25138221,26786319 
