extracytoplasmic thioredoxin, cytochrome c biogenesis, reduces disulfide bonds in apo-cytochrome prior to the attachment of heme
function
cytochrome c biogenesis
product
extracytoplasmic thioredoxin
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.4|Respiration/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|respiration]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|PhoP regulon], [SW|ResD regulon]Gene
Coordinates on the chromosome (coding sequence)
2,420,804 -> 2,421,343
Phenotypes of a mutant
essential according to [http://www.ncbi.nlm.nih.gov/pubmed/12682299 Kobayashi et al.], but inactivation of ''resA'' was reported by [http://www.ncbi.nlm.nih.gov/pubmed/12637552 Erlendsson et al.] and by [http://www.ncbi.nlm.nih.gov/pubmed/26735940 Meeske et al. ]inactivation of ''[SW|resA]'' reduces sporulation efficiency to 45.6% that of wild type cells; delayed entry into sporulation [Pubmed|26735940]The protein
Protein family
ResA subfamily (according to Swiss-Prot)Structure
[PDB|3C73]Expression and Regulation
[SW|Sigma factor]
[protein|search|SigA] [Pubmed|8631715]Regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|9988472]repressed by glucose ([protein|search|CcpA]) [Pubmed|16825793]Regulatory mechanism
[protein|search|ResD]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed][protein|search|PhoP]: transcription activation [Pubmed|9988472][protein|search|CcpA]: transcription repression [Pubmed|16825793]References
8631715,18422485,18456809,8631715,11222591,9988472,16825793,16971393,12637552,26735940 
