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dxs [2019-07-02 10:17:30]

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis

locus

BSU24270

6.00

69.38 kDa

protein length

633 aa Sequence Blast

gene length

1902 bp Sequence Blast

function

biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis

product

1-deoxyxylulose-5-phosphate synthase

essential

yes

2.2.1.7

synonyms

yqiE

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

[category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates

2,523,713 → 2,525,614

Phenotypes of a mutant

essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO₂ (according to Swiss-Prot)

Protein family

DXPS subfamily (according to Swiss-Prot)

Structure

[PDB|2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]

Expression and Regulation

Operons

genes

description

[pubmed|22383849]

regulatory mechanism

regulation

[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

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References

Reviews

19348578

Original publications

12882400,17135236,21296950,23840410,27856234