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dxs [Mon Nov 21 2016 12:40:24 GMT+0100 (CET)]
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dxs [Mon Nov 21 2016 12:40:24 GMT+0100 (CET)]

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis
locus
BSU24270
pI
6.00
mw
69.00 kDa
function
biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis
product
1-deoxyxylulose-5-phosphate synthase
essential
yes
ec
2.2.1.7
synonyms
yqiE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of lipids], [SW|biosynthesis of cofactors], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,523,713 -> 2,525,614

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • Pyruvate D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate CO2 (according to Swiss-Prot)

    • Protein family

  • DXPS subfamily (according to Swiss-Prot)

    • Structure

  • [http://www.proteopedia.org/wiki/index.php/2o1s 2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]

    • Expression and Regulation

    Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

    • References

    Reviews

  • 19348578

    • Original publications

  • 12882400,17135236,21296950,23840410