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dxs [2019-08-07 11:13:19]

1-deoxyxylulose-5-phosphate synthase, first step in the MEP pathway of isoprenoid biosynthesis

locus

BSU_24270

6.00

69.38 kDa

protein length

633 aa Sequence Blast

gene length

1902 bp Sequence Blast

function

biosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis

product

1-deoxyxylulose-5-phosphate synthase

essential

yes

2.2.1.7

synonyms

yqiE

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

[category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates

2,523,713 → 2,525,614

Phenotypes of a mutant

essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO₂ (according to Swiss-Prot)

Protein family

transketolase family (with [protein|000E237B00539E6850B6A50EE01BA02844B6ACBC|Tkt], according to UniProt)

Structure

[PDB|2O1S] (from ''E. coli'', 44% identity, 62% similarity) [Pubmed|17135236]

Expression and Regulation

Operons

genes

description

[pubmed|22383849]

regulatory mechanism

regulation

[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

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References

Reviews

19348578

Original publications

12882400,17135236,21296950,23840410,27856234