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resE
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resE

two-component sensor kinase, regulation of aerobic and anaerobic respiration
locus
BSU_23110
pI
5.34
mw
66.60 kDa
protein length
589 aa Sequence Blast
gene length
1770 bp Sequence Blast
function
regulation of aerobic and anaerobic respiration
product
two-component sensor kinase
essential
no
synonyms
ypxE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.1|Regulators of electron transport]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

    • Gene

    Coordinates
    2,415,415 → 2,417,184

    The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation, phosphorylation of [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]
  • ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)

    • Paralogous protein(s)

  • [protein|C81F68521F17861D50926D7D8757DC1D2340BC0D|PhoR], [protein|E88978809272FAC2520DB4ABCA0554F8028F3451|WalK]

    • [SW|Domains]

  • two transmembrane segments
  • [SW|HAMP domain] (aa 194-246) (according to UniProt)
  • [SW|PAS domain] (aa 253-320) (according to UniProt)
  • [SW|Histidine kinase domain] (aa 371-589) (according to UniProt)

    • Modification

  • autophosphorylation on a His residue

    • Structure

  • [PDB|4ZR7] (N-terminal domain)

    • [SW|Localization]

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]-[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
    description
    [Pubmed|22383849]
    view in new tab

    genes
    [gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
    description
    [Pubmed|8631715]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8631715], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: activation, [PubMed|8631715,11222591], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon]
  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]: activation, [Pubmed|9988472], in [regulon|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|16825793], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
    • view in new tab

    genes
    [gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
    description
    [Pubmed|8631715]

    regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
    • view in new tab

    Biological materials

    Mutant

  • BKE23110 (Δ[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23110 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCTACTACGCTTTTCCAAA, downstream forward: _UP4_TAAAATCGAGTCTGAATTTG
  • BKK23110 (Δ[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23110 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCCTACTACGCTTTTCCAAA, downstream forward: _UP4_TAAAATCGAGTCTGAATTTG

    • References

    Reviews

  • 23046954

    • Original publications

  • 16885456,8631715,10094672,8682783,9352926,8631715,11222591,9988472,16825793,26297017,25909364,28899391