Na transporter subunit of the Na /H antiporter, multiple resistance and pH homeostasis
product
Na /H antiporter subunit
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|metal ion homeostasis (K, Na, Ca, Mg)], [SW|essential genes], [SW|membrane proteins]Gene
Coordinates on the chromosome (coding sequence)
3,246,679 -> 3,249,003
Phenotypes of a mutant
essential [Pubmed|12682299]a ''[protein|search|mrpA]'' mutant is viable at pH7.4 and sodium concentrations below 80 mM [Pubmed|24139955]the ''[protein|search|mrpA]'' mutant accumulates internal sodium [Pubmed|24139955]The protein
Catalyzed reaction/ biological activity
Na transporter subunit of the Na /H antiporter [Pubmed|21236240]Structure
[PDB|4HE8] (from ''Thermus thermophilus'', 36% identity in a 57% fragment) [Pubmed|23417064][SW|Localization]
inner spore membrane [Pubmed|26731423][SW|Interactions]
[protein|search|MrpA]-[protein|search|MrpB]-[protein|search|MrpC]-[protein|search|MrpD]-[protein|search|MrpE]-[protein|search|MrpF]-[protein|search|MrpG] (complex)Expression and Regulation
Operon
''[protein|search|mrpA]-[protein|search|mrpB]-[protein|search|mrpC]-[protein|search|mrpD]-[protein|search|mrpE]-[protein|search|mrpF]-[protein|search|mrpG]'' [Pubmed|9274030,10198001]Biological materials
Mutant
MGNA-B557 (yufT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1556 NBRP B. subtilis, Japan]References
15019740,11004162,17693497,10198001,19389778,16730649,21236240,24021651,24095649,24139955,26731423,23417064 
