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ppsB [2019-04-16 12:27:49]
function
production of the antibacterial compound plipastatin
product
plipastatin synthetase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]Gene
Coordinates
1,982,565 → 1,990,247
The protein
Protein family
ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)Structure
[PDB|2VSQ] (termination module of [protein|1D5F227860A321506A1AB4BAE63CAD3A66E43BFC|SrfAC], 38% identity) [pubmed|18583577]Expression and Regulation
Operons
genes
[gene|E3D7EF8F165CAC2682B0D620081C5C6E555E43C4|ppsA]-[gene|E7A2F93B33B1899313893D362D92405232BC9097|ppsB]-[gene|D11CE89E2AC2ADE3FEFEC261E295EC5906CE6407|ppsC]-[gene|E73D9F1A8F54DAD4B2056CABBE580D7AD36CB042|ppsD]-[gene|C1C051209943E02369356075EAA733297E9478CB|ppsE]
description
[Pubmed|20817675]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, [Pubmed|20817675], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]view in new tabBiological materials
Mutant
BKE18330 (Δ[gene|E7A2F93B33B1899313893D362D92405232BC9097|ppsB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE18330 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAATTCCACACACCTTT, downstream forward: _UP4_AAACTATAGGAGAGGAGATTBKK18330 (Δ[gene|E7A2F93B33B1899313893D362D92405232BC9097|ppsB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK18330 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAATTCCACACACCTTT, downstream forward: _UP4_AAACTATAGGAGAGGAGATTReferences
10471562,9387222,20817675,18583577 
