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hemH

coproporphyrin ferrochelatase

locus

BSU_10130

4.62

35.19 kDa

protein length

310 aa Sequence Blast

gene length

933 bp Sequence Blast

function

biosynthesis of heme

product

coproporphyrin ferrochelatase

essential

4.99.1.1

synonyms

hemF

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

Gene

Coordinates

1,087,250 → 1,088,182

The protein

Catalyzed reaction/ biological activity

coproporphyrin --> coproheme [pubmed|25646457]

2 H⁺ + heme b --> Fe²⁺ + protoporphyrin IX (according to UniProt)

Protein family

ferrochelatase family (with [protein|8BAB9B12D9D58A45446DC6CB7F48869089800FD3|YlnF], according to UniProt)

Structure

[PDB|2HK6] (complex with iron) [pubmed|17198378]

[PDB|1AK1] [pubmed|9384565]

[SW|Localization]

cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

genes

description

[Pubmed|1459957]

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Biological materials

Mutant

BKE10130 (Δ[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG

BKK10130 (Δ[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG

References

Reviews

28123057

Original Publications

9384565,1459957,8119288,21052751,23097001,16453119,25826316,28864672,17198378,9384565,12761666,10704318,25646457