SubtiBank SubtiBank
ytaG
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ytaG

dephospho-CoA kinase
locus
BSU_29060
pI
4.86
mw
21.87 kDa
protein length
197 aa Sequence Blast
gene length
594 bp Sequence Blast
function
synthesis of coenzyme A
product
dephospho-CoA kinase
essential
yes
ec
2.7.1.24
synonyms
coaE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue]

    • Gene

    Coordinates
    2,970,922 → 2,971,515

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • 3'-dephospho-CoA + ATP --> ADP + CoA + H+ (according to UniProt)

    • Protein family

  • coaE family (single member, according to UniProt)

    • [SW|Domains]

  • DPCK domain (aa 4-197) (according to UniProt)

    • Modification

  • phosphorylated on ser/ thr/ tyr [Pubmed|16493705]

    • Structure

  • [PDB|1N3B] (from ''Escherichia coli'', 40% identity, 60% similarity) [Pubmed|12538896]

    • Expression and Regulation

    Operons

    genes
    [gene|3D6DA8B52A4CB49361E67906140696FFA1EF6099|polA]-[gene|EC96EDED2472607DFA4C5EBA054157F7832EE41C|mutM]-[gene|3BEE8E248BC583FCCB37B7A209A122DD93CD398C|ytaF]-[gene|E163A282560DB882B81E783E7E95E1960F4AE4D2|ytaG]
    description
    [pubmed|22383849]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|23396918], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
    • view in new tab

    genes
    [gene|E163A282560DB882B81E783E7E95E1960F4AE4D2|ytaG]
    description
    [Pubmed|9387221]
    view in new tab

    Biological materials

    Mutant

  • MGNA-A118 (ytaG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/118 NBRP B. subtilis, Japan]

    • References

  • 16493705,9387221,11292795,12538896