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sodF
function
detoxification of oxygen radicals
product
superoxide dismutase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]Gene
Coordinates
2,104,056 → 2,104,901
The protein
Catalyzed reaction/ biological activity
2 superoxide + 2 H+ --> O2 + H2O2 (according to UniProt)Protein family
iron/manganese superoxide dismutase family (with [protein|6153A07B961017052E1072944B59F510D80CEC0F|SodA], according to UniProt)Paralogous protein(s)
[protein|6153A07B961017052E1072944B59F510D80CEC0F|SodA] [SW|Cofactors]
contains an iron-sulfur clusterStructure
[PDB|3EVK] (aa 80 ... 280, from Pyrobaculum aerophilum, 54% identity)Expression and Regulation
Operons
genes
[gene|24EB23F594F2B0EEA2E055857BA14FD9E361E0FD|sqhC]-[gene|E0645DD4A7A871457300139A7E5986EF11C07387|sodF]
description
[Pubmed|18436644]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|15699190,18436644], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]regulation
expressed during sporulation in the mother cell [Pubmed|18436644]view in new tabBiological materials
Mutant
BKE19330 (Δ[gene|E0645DD4A7A871457300139A7E5986EF11C07387|sodF]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE19330 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTGAACATCTCCGCTTGAT, downstream forward: _UP4_TAAAAAAAGCCCCCTTTCCTBKK19330 (Δ[gene|E0645DD4A7A871457300139A7E5986EF11C07387|sodF]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK19330 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTGAACATCTCCGCTTGAT, downstream forward: _UP4_TAAAAAAAGCCCCCTTTCCTReferences