radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production
function
antilisterial bacteriocin (subtilosin) production
product
radical S-adenosylmethionine enzyme
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|ResD regulon], [SW|Rok regulon]Gene
Coordinates on the chromosome (coding sequence)
3,836,323 -> 3,837,669
The protein
Catalyzed reaction/ biological activity
catalyzes thioether bond formation in subtilosin A [Pubmed|22366720][SW|Cofactors]
contains two [4Fe-4S] clusters [Pubmed|22366720]Expression and Regulation
Operon
''[protein|search|sboA]-[protein|search|sboX]-[protein|search|albA]-[protein|search|albB]-[protein|search|albC]-[protein|search|albD]-[protein|search|albE]-[protein|search|albF]-[protein|search|albG]'' [Pubmed|10572140][SW|Sigma factor]
[protein|search|SigA] [Pubmed|xxxxxx] [Pubmed|10572140]Regulation
repressed by [protein|search|Rok] [Pubmed|15743949]expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|10809710]repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10572140,17720793 PubMed]Regulatory mechanism
[protein|search|Rok]: transcription repression [Pubmed|15743949][protein|search|ResD]: transcription activation [Pubmed|10809710][protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10572140,17720793 PubMed]References
10809709,10572140,15743949,10809710,10572140,17720793,17190806 
