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thiL
thiamine-monophosphate kinase
function
biosynthesis of thiamine
product
thiamine-monophosphate kinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]Gene
Coordinates
640,662 → 641,639
The protein
Catalyzed reaction/ biological activity
ATP + thiamine phosphate --> ADP + thiamine diphosphate (according to UniProt)Protein family
thiamine-monophosphate kinase family (single member, according to UniProt)Structure
[PDB|1VQV] (from ''Aquifex aeolicus'', 33% similarity, 51% identity)Expression and Regulation
Operons
genes
[gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]-[gene|E15BB518649B2B9CD44CEBBB4FA481E55BCE823C|tsaE]-[gene|6CB350C335603D5F4434679F9D740BFECA738599|tsaB]-[gene|C2283BDD806221A285A27F24F52F92F4D47F0C55|ydiD]-[gene|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-C197 (ydiA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2195 NBRP B. subtilis, Japan]BKE05900 (Δ[gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE05900 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAACCAAAACCTCCTTT, downstream forward: _UP4_TTTAAATAAGACGGGTGACTBKK05900 (Δ[gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK05900 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAACCAAAACCTCCTTT, downstream forward: _UP4_TTTAAATAAGACGGGTGACTReferences
Reviews
Original publications
