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bpr
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bpr

bacillopeptidase F
locus
BSU_15300
pI
4.98
mw
154.34 kDa
protein length
1433 aa Sequence Blast
gene length
4302 bp Sequence Blast
function
protein degradation
product
bacillopeptidase F
essential
no
synonyms
bpf
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.5|Utilization of proteins]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.2|Extracellular feeding proteases]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • Gene

    Coordinates
    1,599,283 → 1,603,584

    The protein

    Protein family

  • [SW|peptidase S8 family] (according to UniProt)

    • [SW|Domains]

  • Inhibitor I9 domain (aa 68-177) (according to UniProt)
  • Peptidase S8 domain (aa 200-512) (according to UniProt)

    • Structure

  • [PDB|6PAK] ([protein|0B98DE9CE2D98FFDE9F6EEB4E94FA1E5204BD48D|AprE], corresponds to aa 199 ... 507, 32% identity) [pubmed|31615894]

    • [SW|Localization]

  • secreted (according to Swiss-Prot), extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operons

    genes
    [gene|D5EBF5881EB3F89C9098DDE6EF18C8EBB02A278C|bpr]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]-P [Pubmed|18194340], in [regulon|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU regulon]

    • regulation

  • repressed by glucose (7.7-fold) [Pubmed|12850135]
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    Biological materials

    Mutant

  • KO7 (''ΔnprE ΔaprE Δepr Δmpr ΔnprB Δvpr Δbpr''), available as BGSC 1A1133
  • BKE15300 (Δ[gene|D5EBF5881EB3F89C9098DDE6EF18C8EBB02A278C|bpr]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCATCCCCCTTTTTC, downstream forward: _UP4_TAAGTGGAAAAAAAGCTGCC
  • BKK15300 (Δ[gene|D5EBF5881EB3F89C9098DDE6EF18C8EBB02A278C|bpr]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTCATCCCCCTTTTTC, downstream forward: _UP4_TAAGTGGAAAAAAAGCTGCC

    • References

    Reviews

  • 20735481

    • Original publications

  • 2106512,18414485,18194340,24149708,18957862,12850135,24115457,31615894