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pyrAB [Fri Dec 04 2015 20:54:45 GMT+0100 (CET)]
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pyrAB [Fri Dec 04 2015 20:54:45 GMT+0100 (CET)]

carbamoyl-phosphate synthetase (catalytic subunit)
locus
BSU15520
pI
4.00
mw
117.00 kDa
function
pyrimidine biosynthesis
product
carbamoyl-phosphate synthetase (catalytic subunit)
essential
no
ec
6.3.5.5
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|PyrR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,623,736 -> 1,626,951

    The protein

    Catalyzed reaction/ biological activity

  • 2 ATP L-glutamine HCO3- H2O = 2 ADP phosphate L-glutamate carbamoyl phosphate (according to Swiss-Prot)
  • Protein family

  • carB family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|CarB]
  • Structure

  • [PDB|1JDB] (from ''Escherichia coli'', 49% identity, 69% similarity) [Pubmed|10089390]
  • [SW|Localization]

  • membrane [Pubmed|18763711]
  • [SW|Interactions]

  • [SW|PyrAA]-[SW|PyrAB] [Pubmed|12859215]
  • Expression and Regulation

    Operon

  • ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1709162]
  • Regulation

  • induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]
  • Regulatory mechanism

  • [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]
  • References

    Reviews

  • 12859215,11395405
  • Original publications

  • 8206849,1709162,18763711,10089390,8663035