response regulator aspartate phosphatase (RapA) inhibitor, control of the phosphorelay
function
control of sporulation initiation
product
phosphatase (RapA) inhibitor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.6|Other protein controlling the activity of the phosphorelay][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.6|Other protein controlling the activity of the phosphorelay][category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides][SW|Categories] containing this gene/protein
[SW|phosphorelay], [SW|quorum sensing], [SW|short peptides]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|ComA regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,316,995 -> 1,317,129
The protein
Protein family
phr family (according to Swiss-Prot)[SW|Interactions]
[protein|search|RapA]-[protein|search|PhrA] [Pubmed|11923303,22267516]Expression and Regulation
Operon
''[protein|search|rapA]-[protein|search|phrA]'' [Pubmed|1378051][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1378051]Regulation
repressed by glucose (4.2-fold) ([protein|search|CcpA]) [Pubmed|12850135]repressed by casamino acids [Pubmed|12107147]repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|CcpA]: transcription repression[SW|Spo0A]: transcription repression [Pubmed|14651647][protein|search|CodY]: transcription repression [Pubmed|12618455]References
8643670,8730857,11923303,1378051,14651647,12618455,12107147,19380751,16091051,20238180 
