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folK [Tue Jan 03 2017 14:51:17 GMT+0100 (CET)]
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folK [Tue Jan 03 2017 14:51:17 GMT+0100 (CET)]

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
locus
BSU00790
pI
4.00
mw
18.00 kDa
function
biosynthesis of folate
product
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
essential
no
ec
2.7.6.3
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • Gene

    Coordinates on the chromosome (coding sequence)
    86,946 -> 87,449

    The protein

    Catalyzed reaction/ biological activity

  • ATP 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate (according to Swiss-Prot)

    • Protein family

  • HPPK family (according to Swiss-Prot)

    • Structure

  • [PDB|1IM6] (from ''Escherichia coli'', 47% identity, 61% similarity) [Pubmed|12578370]

    • Expression and Regulation

    Operon

  • ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9084182]

    • References

    Reviews

  • 28031352

    • Original publications

  • 9084182