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folK [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
function
biosynthesis of folate
product
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors]The protein
Catalyzed reaction/ biological activity
ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate (according to Swiss-Prot)Protein family
HPPK family (according to Swiss-Prot)Structure
[PDB|1IM6] (from ''Escherichia coli'', 47% identity, 61% similarity) [Pubmed|12578370]Expression and Regulation
Operon
''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9084182]References
