function
uptake of copper
product
copper transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.1|Copper][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|YcnK regulon]Gene
Phenotypes of a mutant
growth-defective under copper-limiting conditions [Pubmed|19168619]The protein
Catalyzed reaction/ biological activity
uptake of copper [Pubmed|19168619][SW|Localization]
cell membrane [Pubmed|19168619]Expression and Regulation
Operon
''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' [Pubmed|22904286,22383849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|22904286]Regulation
induced by copper limitation ([protein|search|YcnK]) [Pubmed|22904286,19168619]induction of the ''[protein|search|ycnK]-[protein|search|ycnJ]-[protein|search|ycnI]'' in a ''[protein|search|csoR]'' mutant results from intracellular copper depletion due to the constitutive expression of the ''[protein|search|copZ]-[protein|search|copA]'' operon (copper export) [Pubmed|22904286]Regulatory mechanism
[protein|search|YcnK]: transcription repression [Pubmed|22904286,19168619]Labs working on this gene/protein
[SW|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]References
19168619,22904286,22383849 
