You are currently viewing an outdated version of
SubtiWiki.
Please use
the newest version!
ilvA [Mon May 16 2016 16:52:54 GMT+0200 (CEST)]
function
biosynthesis of branched-chain amino acids
product
threonine dehydratase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.12|Biosynthesis/ acquisition of branched-chain amino acids][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
2,292,769 -> 2,294,037
The protein
Catalyzed reaction/ biological activity
L-threonine = 2-oxobutanoate NH3 (according to Swiss-Prot) Protein family
ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)Structure
[PDB|1TDJ] (the enzyme from ''E. coli'', 39% identity) [Pubmed|9562556]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed] Expression and Regulation
Operon
''[protein|search|ilvA]-[protein|search|ypmP]'' [Pubmed|15060025]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|12618455]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed] Biological materials
lacZ fusion
pGP519 (in [protein|search|pAC5]), available in [SW|Stülke] labReferences
18083814,12618455,15060025,9562556,12618455,12107147,24163341,26220295