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ilvA [Mon May 16 2016 16:52:54 GMT+0200 (CEST)]
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ilvA [Mon May 16 2016 16:52:54 GMT+0200 (CEST)]

threonine dehydratase
locus
BSU21770
pI
5.00
mw
46.00 kDa
function
biosynthesis of branched-chain amino acids
product
threonine dehydratase
essential
no
ec
4.3.1.19
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.12|Biosynthesis/ acquisition of branched-chain amino acids]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,292,769 -> 2,294,037

    The protein

    Catalyzed reaction/ biological activity

  • L-threonine = 2-oxobutanoate NH3 (according to Swiss-Prot)
  • Protein family

  • ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
  • Structure

  • [PDB|1TDJ] (the enzyme from ''E. coli'', 39% identity) [Pubmed|9562556]
  • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]
  • Expression and Regulation

    Operon

  • ''[protein|search|ilvA]-[protein|search|ypmP]'' [Pubmed|15060025]
  • Regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|12618455]
  • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17981983 PubMed]
  • Biological materials

    lacZ fusion

  • pGP519 (in [protein|search|pAC5]), available in [SW|Stülke] lab
  • References

  • 18083814,12618455,15060025,9562556,12618455,12107147,24163341,26220295