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ylyB
similar to pseudouridylate synthase
function
RNA modification
product
putative pseudouridylate synthase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.3|rRNA modification and maturation/ based on similarity]Gene
Coordinates
1,617,210 → 1,618,121
The protein
Catalyzed reaction/ biological activity
uridine in RNA --> pseudouridine in RNA (according to UniProt)Protein family
[SW|S4 RNA-binding domain] superfamily (according to http://www.ebi.ac.uk/interpro/entry/IPR036986 Interpro)pseudouridine synthase RluA family (with [protein|2AECDA9C4D0E704976B9E2168722EC80FE7A256D|YjbO] and [protein|064AE8CE6D52E35582F90654AA9548963573C05C|YhcT], according to UniProt)Paralogous protein(s)
[protein|064AE8CE6D52E35582F90654AA9548963573C05C|YhcT], [protein|2AECDA9C4D0E704976B9E2168722EC80FE7A256D|YjbO] [SW|Domains]
[SW|S4 RNA-binding domain] (aa 15-74) (according to UniProt)Structure
[PDB|1V9F] (RluD from E. coli, 42% identical) [pubmed|15078091]Expression and Regulation
Operons
genes
[gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]-[gene|C8C2E2F1B739F3D9A2FA6B460998708AAB2DA495|ylyB]-[gene|6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE15460 (Δ[gene|C8C2E2F1B739F3D9A2FA6B460998708AAB2DA495|ylyB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGCGGTTATATCAATTTGAT, downstream forward: _UP4_TGACAGAGGGTTTCTTTTCTBKK15460 (Δ[gene|C8C2E2F1B739F3D9A2FA6B460998708AAB2DA495|ylyB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGCGGTTATATCAATTTGAT, downstream forward: _UP4_TGACAGAGGGTTTCTTTTCTReferences
