1,2,-dihydroxy-3-keto-5-methylthiopentene dioxygenase
function
methionine salvage
product
1,2,-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|S-box]Gene
Coordinates on the chromosome (coding sequence)
1,429,584 -> 1,430,120
The protein
Catalyzed reaction/ biological activity
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one O2 = 3-(methylthio)propanoate formate CO (according to Swiss-Prot)Protein family
acireductone dioxygenase (ARD) family (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|mtnW]-[protein|search|mtnX]-[protein|search|mtnB]-[protein|search|mtnD]'' [Pubmed|12022921][SW|Sigma factor]
[protein|search|SigA] [Pubmed|12022921]Regulation
repressed by casamino acids [Pubmed|12107147]induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
12022921,11914366,12107147,15102328,12787499,18039762,15378759 
