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reoM
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reoM

effector protein of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|MurAA] degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|ClpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]
locus
BSU_27400
pI
4.73
mw
10.10 kDa
protein length
88 aa Sequence Blast
gene length
267 bp Sequence Blast
function
control of peptidoglycan biosynthesis
product
regulator of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|MurAA] degradation
essential
no
synonyms
yrzL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other]

    • Gene

    Coordinates
    2,797,823 → 2,798,089

    Phenotypes of a mutant

  • accumulation of [protein|DA763F7C2192655C590752C2A285ADF902B11BCA|MurAA] due to reduced degradation by [protein|86A2F2F65290F4471D6FD03B694821C66C180D8A|ClpC]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP] [pubmed|32469310]

    • The protein

    Protein family

  • UPF0297 family (single member, according to UniProt)

    • Structure

  • [PDB|5US5] (from Enterococcus faecalis, 66% identity) [pubmed|28551334]
  • [PDB|6TIF] (from Listeria monocytogenes, 68% identity) [pubmed|32469310]

    • Expression and Regulation

    Operons

    genes
    [gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]-[gene|508FC7117B4CE7AF119B3830AE9DC113CB058039|yrrK]-[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]
    description
    [pubmed|22383849]
    view in new tab

    genes
    [gene|8C5C7F9A585AE89D53EAF1DB3A9AB525B9E30B4A|alaS]-[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]-[gene|508FC7117B4CE7AF119B3830AE9DC113CB058039|yrrK]-[gene|A0AA5289F5E92A4B2E18E4F3439F2D412208826E|yrzB]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|T-box|T-box]: antitermination, in [regulon|T-box|T-box]

    • regulation

  • induced by alanine limitation ([regulon|T-box|T-box]) [Pubmed|19258532]
    • view in new tab

    Biological materials

    Mutant

  • BKE27400 (Δ[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTGCACCTCTTTC, downstream forward: _UP4_CAGCATAAAGAGGCGTAAAT
  • BKK27400 (Δ[gene|C5457FEC46A1AFC6E5B1148B0E5F258B2C3197B2|reoM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27400 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACCGTTTTGCACCTCTTTC, downstream forward: _UP4_CAGCATAAAGAGGCGTAAAT

    • References

    Research papers

  • 32469310,28551334