anti-repressor, antagonist of eps and tapA-sipW-tasA operons
function
control of biofilm formation
product
antagonist of SinR and SlrR
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.6|Transition state regulators][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|transition state regulators], [SW|biofilm formation]This gene is a member of the following [SW|regulons]
[SW|YwcC regulon]Gene
Coordinates on the chromosome (coding sequence)
3,923,319 -> 3,923,477
The protein
Catalyzed reaction/ biological activity
binding of [protein|search|SinR] resulting in induction of [protein|search|SinR]-repressed genes and operons [Pubmed|19788541]Paralogous protein(s)
[protein|search|SinI]Effectors of protein activity
[protein|search|SlrR] inhibits activity of [protein|search|SlrA] (i. e. binding to [protein|search|SinR]) [Pubmed|19788541][SW|Interactions]
[protein|search|SlrA]-[protein|search|SinR] [Pubmed|19788541], K(D) 10.6 nM [Pubmed|23430750][protein|search|SlrA]-[protein|search|SlrR] [Pubmed|19788541]Expression and Regulation
Operon
''[protein|search|slrA]-[protein|search|ywcB]-[protein|search|ywcA]''[protein|search|slrA]-[protein|search|ywcB]''[protein|search|slrA]Regulatory mechanism
[protein|search|YwcC]: transcription repression [Pubmed|18647168,19788541]Additional information
the mRNA accumulates in a ''[SW|pnpA]'' mutant [Pubmed|26857544]Biological materials
two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Stülke] labReferences
18647168,19788541,23430750,26857544 
