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slrA [2017-06-07 11:53:06]
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slrA [2017-06-07 11:53:06]

anti-repressor, antagonist of eps and tapA-sipW-tasA operons
locus
BSU38229
pI
9.00
mw
6.00 kDa
protein length
52 aa Sequence Blast
gene length
156 bp Sequence Blast
function
control of biofilm formation
product
antagonist of SinR and SlrR
essential
no
synonyms
Outlinks
KEGGBsubCycUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.6|Transition state regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.4|Regulation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming]

    • Gene

    Coordinates
    3,923,319 → 3,923,477

    The protein

    Catalyzed reaction/ biological activity

  • binding of [protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR] resulting in induction of [protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR]-repressed genes and operons [Pubmed|19788541]

    • Paralogous protein(s)

  • [protein|24D6A7DDCB25B99FBB670E9203F826596916B35C|SinI]

    • Effectors of protein activity

  • [protein|920F91E748EE079FF864011D9052B073567C41E4|SlrR] inhibits activity of [protein|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|SlrA] (i. e. binding to [protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR]) [Pubmed|19788541]

    • Expression and Regulation

    Operons

    genes
    [gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [protein|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|YwcC]: repression, [Pubmed|18647168,19788541], in [regulon|C3D87DAA8DB124D50D2C2B2D424C9608C0DE067F|YwcC regulon]

    • additional information

  • increased expression in a [gene|64C6D783FF3F41C81B216F798A1DC8071345B1ED|pnpA] mutant [Pubmed|26857544]
  • half-life of the mRNA: 0.56 min, this increases to 1.06 in a [gene|64C6D783FF3F41C81B216F798A1DC8071345B1ED|pnpA] mutant [Pubmed|26857544]
  • RNA degradation by [protein|64C6D783FF3F41C81B216F798A1DC8071345B1ED|PnpA] is proceeds from the 3' end of the mRNA through the [protein|7CD46C64BE69EDADF58B634DC50C3F61BFFEC5B5|Rho]-dependent terminator [Pubmed|26857544]
  • transcription termination depends on [protein|7CD46C64BE69EDADF58B634DC50C3F61BFFEC5B5|Rho] [Pubmed|26857544]
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    Biological materials

    two-hybrid system

  • B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Stülke] lab

    • References

  • 18647168,19788541,23430750,26857544