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liaF [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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liaF [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

inhibitor of LiaS kinase activity
locus
BSU33100
pI
9.00
mw
26.00 kDa
function
control of LiaR activity
product
negative effector of LiaS
essential
no
synonyms
yvqF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|LiaR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,396,114 -> 3,396,839

    The protein

    Catalyzed reaction/ biological activity

  • inhibitor of [protein|search|LiaS] kinase activity, maintains [protein|search|LiaS] in the phosphatase state in the absence of the stress signal [Pubmed|23279150]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]
  • ''[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|16816187]

    • [SW|Sigma factor]

  • ''liaI'': [protein|search|SigA] [Pubmed|15273097]
  • ''liaG'': [protein|search|SigA] [Pubmed|16816187]

    • Regulation

  • ''[protein|search|liaI]'': induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]
  • ''[protein|search|liaI]'': repressed during logarithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]
  • ''[protein|search|liaG]'': constitutive

    • Regulatory mechanism

  • [protein|search|LiaR]: transcription activation [Pubmed|16816187]

    • References

    Reviews

  • 27344142

    • Original publications

  • 19164152,20639339,15273097,17660417,16816187,15101989,17660417,16816187,23279150,20817675,22092710,23326432