major component of biofilm matrix, forms amyloid fibers
function
biofilm formation
product
major component of biofilm matrix
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.2|Amyloid protein synthesis, secretion and assembly][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|biofilm formation]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|RemA regulon], [SW|SinR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,553,081 -> 2,553,866
Phenotypes of a mutant
altered cell death pattern in colonies [Pubmed|23012477]The protein
Catalyzed reaction/ biological activity
forms amyloid fibers that bind cells together in the biofilm [Pubmed|20080671]Protein family
peptidase M73 family (according to Swiss-Prot)[SW|Localization]
extracellular (signal peptide) [Pubmed|18957862], secretion requires [protein|search|SipW] [Pubmed|10049401]membrane [Pubmed|18763711][SW|Interactions]
forms fibers of variable length and 10-15 nm in width [Pubmed|20080671][protein|search|TapA]-[protein|search|TasA] [Pubmed|24488317][protein|search|SipW]-[protein|search|TasA] [Pubmed|10049401]Expression and Regulation
Operon
''[protein|search|tapA]-[protein|search|sipW]-[protein|search|tasA]'' [Pubmed|16430695][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16430695]Regulation
repressed by casamino acids [Pubmed|12107147]repressed by [protein|search|SinR] [Pubmed|16430695]repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]Regulatory mechanism
[protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed][protein|search|SinR]: transcription repression [Pubmed|16430695][protein|search|RemA]: transcription activation [Pubmed|23646920]Additional information
induction by sequestration of [protein|search|SinR] by [protein|search|SinI] or [protein|search|SlrA] [PubMed|15661000,19788541] or by SlrR [PubMed|20351052]the '[protein|search|tapA]-[protein|search|sipW]-[protein|search|tasA]' operon is not expressed in a '[protein|search|ymdB]' mutant [PubMed|21856853]the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] (this is likely due to the increased stability of the '[protein|search|sinR]' mRNA) [PubMed|21815947]References
Reviews
20735481,20351052,21488983,24988880,25907113,26418850 Original publications
23352144,23352134,23632024,23012477,21815947,21856853,18047568,16430695,16430696,10368135,18430133,18647168,10464223,17720793,18957862,12107147,18763711,20080671,10049401,23646920,24488317,25894589 
