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ywpB
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ywpB

ß-hydroxyacyl-(acyl carrier protein) dehydratase
locus
BSU_36370
pI
9.36
mw
14.63 kDa
protein length
141 aa Sequence Blast
gene length
426 bp Sequence Blast
function
fatty acid biosynthesis
product
β-hydroxyacyl-ACP dehydratase
essential
yes
ec
4.2.1.59
synonyms
fabZ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    3,743,732 → 3,744,157

    Phenotypes of a mutant

  • essential [Pubmed|23109554]

    • The protein

    Catalyzed reaction/ biological activity

  • (3R)-hydroxyacyl-[ACP] --> (2E)-enoyl-[ACP] + H2O (according to UniProt)

    • Protein family

  • thioester dehydratase family (with [protein|65506215AE58BF53C57599E566E4F78514DB45AA|YcsD], according to UniProt)

    • Paralogous protein(s)

  • [protein|65506215AE58BF53C57599E566E4F78514DB45AA|YcsD]

    • Structure

  • [PDB|3D6X] (from ''Campylobacter jejuni'', 45% identity, 67% similarity) [Pubmed|19280690]

    • Expression and Regulation

    Operons

    genes
    [gene|BDA23FA513C240B07DC109BB62A7A5EB96B20965|ywpB]-[gene|7F7BC285A1D02B031575BA7E980293CD2962C84A|mscL]
    description
    [Pubmed|22383849]

    regulation

  • expressed in logarithmic phase [Pubmed|19252899]
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    Biological materials

    Mutant

  • MGNA-B265 (ywpB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1264 NBRP B. subtilis, Japan]

    • References

  • 17919287,19280690