SubtiBank SubtiBank
spoVM
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

spoVM

required for normal spore cortex and coat synthesis, inhibits the proteolytic activity of [protein|search|FtsH ](adaptor protein)
locus
BSU_15810
pI
11.03
mw
2.88 kDa
protein length
26 aa Sequence Blast
gene length
81 bp Sequence Blast
function
initiation of spore coat assembly
product
spore coat morphogenetic protein
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.1|Class I]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,655,446 → 1,655,526

    Phenotypes of a mutant

  • reduction of sporulation efficiency due to defects in spore coat and cortex assembly [Pubmed|22463703]

    • The protein

    Catalyzed reaction/ biological activity

  • anchors the basement layer of the spore coat to the surface of the developing spore [Pubmed|22463703]
  • preferentially binds to micron-scale convex membranes and marks the surface of the developing spore as the site for coat assembly [pubmed|31597735]
  • recruits [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] to the spore coat [pubmed|31597735]

    • [SW|Domains]

  • contains an amphipathic alpha-helix

    • Structure

  • [PDB|2MVH] [Pubmed|25825747]

    • [SW|Localization]

  • around the surface of the developing forespore [Pubmed|22463703]
  • spore membrane, recognizes membrane curvature [Pubmed|19265022]
  • spore coat (basement), localization depends on [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] [Pubmed|22171814]

    • Expression and Regulation

    Operons

    genes
    [gene|BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055|spoVM]
    description
    [Pubmed|8231808]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|8231808,15699190], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]

    • regulatory mechanism

  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: activation, [Pubmed|8231808], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]

    • regulation

  • expressed in mother cell during sporulation ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|8231808,15699190,19265022]
    • view in new tab

    Biological materials

    Mutant

  • BKE15810 (Δ[gene|BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055|spoVM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTGTCCCCTCCTATA, downstream forward: _UP4_TAATGCCCAGGGGTTCAAAG
  • BKK15810 (Δ[gene|BBDA32A4EE3389D6F4404F7B3DA9E13AC7BF8055|spoVM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTGTCCCCTCCTATA, downstream forward: _UP4_TAATGCCCAGGGGTTCAAAG

    • References

    Reviews

  • 23202530,28408070

    • Original publications

  • 10913836,18820968,8231808,9922240,19265022,12562810,9287010,17427285,19775244,15699190,22463703,22171814,22882210,25625300,25825747,25854653,29102609,31597735