malonyl CoA-acyl carrier protein transacylase
function
fatty acid biosynthesis
product
malonyl CoA-acyl carrier protein transacylase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|ComA regulon], [SW|FapR regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein] (according to Swiss-Prot)Protein family
fabD family (according to Swiss-Prot)Structure
[PDB|1MLA] (the enzyme from ''E. coli'') [Pubmed|7768883]Expression and Regulation
Operon
''[protein|search|fapR]-[protein|search|plsX]-[protein|search|fabD]-[protein|search|fabG]-[protein|search|acpA]'' [Pubmed|12737802,19850612][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16932747]Regulation
induced if the cells experience an accumulation of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|FapR]: transcription repression [Pubmed|12737802]References
Reviews
Original Publications
12737802,16932747,19850612,7768883,16091051 
