glycerol-3-phosphate dehydrogenase (menaquinone 7)
function
glycerol utilization
product
glycerol-3-phosphate dehydrogenase (menaquinone 7)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.3|Utilization of glycerol/ glycerol-3-phosphate][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.1|Utilization of phospholipids][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|utilization of lipids]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CcpA regulon], [SW|GlpP regulon]The protein
Catalyzed reaction/ biological activity
sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol (according to Swiss-Prot)Protein family
FAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)[SW|Cofactors]
FADStructure
[PDB|3DA1] (from ''Bacillus halodurans'', 57% identity, 72% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|glpD]'' [Pubmed|2127799][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1809833]Regulation
repressed by glucose ([protein|search|CcpA])induced by glycerol ([protein|search|GlpP]) [Pubmed|1809833]Regulatory mechanism
[protein|search|CcpA]: transcription repression[protein|search|GlpP]: transcriptional antitermination at a [SW|RNA switch] [Pubmed|1809833][protein|search|AbrB]: transcription activation [Pubmed|20817675]Biological materials
Mutant
QB5347 (cat), available in the [SW|Stülke] labReferences
8825777,1479885,9595668,9493382,20817675 
