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dhbE [Sat May 21 2016 12:50:41 GMT+0200 (CEST)]
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dhbE [Sat May 21 2016 12:50:41 GMT+0200 (CEST)]

2,3-dihydroxybenzoate-AMP ligase (enterobactin synthetase component E)
locus
BSU31980
pI
5.00
mw
59.00 kDa
function
biosynthesis of the siderophore bacillibactin
product
2,3-dihydroxybenzoate-AMP ligase (enterobactin synthetase component E)
essential
no
synonyms
entE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]

    • [SW|Categories] containing this gene/protein

  • [SW|acquisition of iron], [SW|iron metabolism]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|Fur regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,288,641 -> 3,290,260

    The protein

    Protein family

  • ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)

    • Structure

  • [PDB|1MDB] (complex with DHB-adenylate), [PDB|1MDF]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|dhbA]-[protein|search|dhbC]-[protein|search|dhbE]-[protein|search|dhbB]-[protein|search|dhbF]'' [Pubmed|8921902]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8550523]

    • Regulation

  • induced by iron starvation ([protein|search|Fur]) [Pubmed|12354229]

    • Regulatory mechanism

  • [protein|search|Fur]: transcription repression [Pubmed|12354229]
  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]

    • Additional information

  • the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y]
  • [PubMed|21815947]
  • the ''[protein|search|dhbA]-[protein|search|dhbC]-[protein|search|dhbE]-[protein|search|dhbB]-[protein|search|dhbF]'' operon is strongly unregulated in a ''[SW|kre]'' mutant [Pubmed|26110430]

    • Labs working on this gene/protein

  • [SW|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]

    • References

  • 12221282,11112781,11790741,12354229,8921902,8550523,20817675,21815947,24223955,26110430