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dfrA [2019-09-17 11:59:06]

dihydrofolate reductase

locus

BSU_21810

5.22

19.03 kDa

protein length

168 aa Sequence Blast

gene length

507 bp Sequence Blast

function

biosynthesis of folate

product

dihydrofolate reductase

essential

yes

1.5.1.3

synonyms

tmp

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]

[category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates

2,296,603 → 2,297,109

Phenotypes of a mutant

essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

(6S)-5,6,7,8-tetrahydrofolate + NADP⁺ --> 7,8-dihydrofolate + H⁺ + NADPH (according to UniProt)

Protein family

dihydrofolate reductase family (single member, according to UniProt)

Structure

[PDB|1ZDR] (Geobacillus stearothermophilus)

Expression and Regulation

Operons

genes

description

[Pubmed|22383849]

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genes

[gene|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]-[gene|B740E971204AC14BA456B8C93A86D4BDC29524FF|dfrA]

description

[Pubmed|2840350]

regulatory mechanism

[protein|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|CcpN]: activation, weak, in [regulon|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|CcpN regulon]

regulation

weak induction in the presence of glucose ([protein|search|CcpN]) [Pubmed|19732150]

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References

2840350,6436144,3918568,24158440