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liaI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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liaI [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

resistance against oxidative stress and cell wall antibiotics, membrane anchor for LiaH
locus
BSU33130
pI
9.00
mw
13.00 kDa
function
resistance against oxidative stress and cell wall antibiotics
product
membrane anchor for LiaH
essential
no
synonyms
yvqI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|LiaR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,398,550 -> 3,398,930

    The protein

    [SW|Localization]

  • cell membrane [Pubmed|24666271]
  • forms highly dynamic membrane-associated foci under non-inducing conditions [Pubmed|24666271]
  • co-localizes with [protein|search|LiaH] in distinct static spots at the cytoplasma membrane under stress conditions [Pubmed|24666271]

    • [SW|Interactions]

  • [protein|search|LiaI]-[protein|search|LiaH] [Pubmed|24666271]

    • Expression and Regulation

    Operon

  • ''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]
  • ''[protein|search|liaI]-[protein|search|liaH]'' [Pubmed|20639339]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|15273097]

    • Regulation

  • induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]
  • repressed during logarithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15101989,17660417 PubMed], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]
  • repressed by glucose (4.3-fold) [Pubmed|12850135]

    • Regulatory mechanism

  • [protein|search|LiaR]: transcription activation [Pubmed|16816187]

    • Biological materials

    Mutant

  • 1A980 ( ''liaI''::''erm''), [Pubmed|15273097], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A980&Search=1A980 BGSC]

    • References

    Reviews

  • 27344142

    • Original publications

  • 19164152,15273097,17660417,17600057,20057163,16816187,15101989,17660417,12850135,16816187,20639339,20817675,22092710,24666271